Electrochemical CO2 reduction holds great promise in reducing atmospheric CO2 concentration. However, several challenges hinder the commercialization of this technology. Energy efficiency, CO2 solubility in aqueous phase, and electrode stability are among the current issues. In this mini-review, we summarize and highlight the main advantages and limitations that Metal-Organic Frameworks may offer to this field of research, either when used directly as electrocatalysts or when used as catalyst precursors.